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China's dominance in the titanium dioxide market is a testament to its robust industrial infrastructure and advanced chemical processing capabilities. According to industry reports, China accounts for more than half of the global titanium dioxide production, making it the largest producer and exporter of this pigment worldwide. This is largely due to the country's abundant reserves of titanium-bearing minerals, such as ilmenite and rutile, which are the primary raw materials for TiO2 production.

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In vitro, in the hemocytes of the marine mussel Mytilus hemocytes, suspension of TiO2 NPs (Degussa P25, 10 μg/ml) stimulated immune and inflammatory responses, such as lysozyme release, oxidative burst and nitric oxide production. Vevers and Jha demonstrated the intrinsic genotoxic and cytotoxic potential of TiO2 NPs on a fish-cell line derived from rainbow-trout gonadal tissue (RTG-2 cells) after 24 h of exposure to 50 μg/ml. Reeves et al. demonstrated a significant increase in the level of oxidative DNA damage in goldfish cells, and suggested that damage could not repaired by DNA repair mechanisms. Another suggestion from the mentioned study was that hydroxyl radicals are generated also in the absence of UV light. It has been shown that fish cells are generally more susceptible to toxic/oxidative injury than mammalian cells.

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